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microneedling: My Services
Glass Skin Mesotherapy
Glass Skin Mesotherapy is an amazing treatment involving Microneedling Stamping technique and No needle mesotherapy to infuse formulations of active ingredients into the epidermal and dermal layers of the skin, allowing these ingredients to work at maximum effectiveness.
✔Little to no downtime
✔Effective for all skin types, light to dark
✔Comfortable experience and ideal any time of the year
✔Short procedure time
✔Real results from a safe, natural and minimally invasive procedure
✔Clinically proven safe and effective
Mesococtails we use during Glass skin Mesotherapy:
COMPOSITION: Hyaluronic acid, isoleucine, Leucine, Lysine, Proline, Valine, Glycine, Serine, Alanine, Cysteine, Phosphate buffer system
MESORGA® BIOREJ is, in fact, made up entirely of fragments of hyaluronic acid in the range between 20 and 38 monomers and precursor amino acids of collagen, elastin and glycosaminoglycans: among these, Leucine and Isoleucine are two essential amino acids that our body cannot produce on its own, known to support the production of growth hormones, responsible for tissue reproduction and to counteract hair loss; moreover, the combination with the other amino acids Glycine and Proline helps to improve the appearance of the skin due to the function of restoring and increasing hydration, firmness and elasticity.
Lysine plays an essential role in the production of collagen providing stability and resistance to traction of the skin, helping to maintain the tone of the skin surface by strengthening its supporting elements as well as having a repairing function for damaged skin and hair.
Valine, on the other hand, is necessary for the normal functioning of the skin and is very important for the strength of the tissues of our skin.
Cysteine is used to produce the vital antioxidant Glutanion (tripeptide of glutamate, cysteine and glycine) for the detoxification of the skin from all types of pollution and oxidative stress.
Alanine and Serin are part of the non-essential amino acids, or rather those that our body is able to produce, but which are still important:
• Alanine for the elaboration of vitamin B as an anti-inflammatory and also to support the detoxification of the organism;
• Serine which contributes to the production of globulins and antibodies and has very important natural moisturizing properties.
Mesorga® Biorej is also equipped with a bicarbonate-based buffer system, through which, by buffering the acidity of the matrix, it maintains the sol state of the colloidal solution, facilitating metabolic exchange.
Hyaluronic acid (HA) is a polysaccharide with extraordinary properties. It’s a large linear polymer, negatively charged, composed of the repetition of disaccharidic units of D-glucu-ronic acid and N-acetyl-D-glucosamine, joined together by glycosydic bonds.
It is the main component of the extracellular matrix (ECM), belongs to the family of glycosaminoglycans (GAG) and is a very large molecule. Within our organism we find it distributed in the form of salt and in high concentrations mainly in connective tissue, in the skin, umbilical cord, synovial fluid, vitreous humor, but also in the lungs, kidneys, brain and muscles.
In recent years, multiple investigations have been carried out which have led to the awareness that HA is synthesized on the inner surface of the cell plasma membrane. The formed chains are then extruded into extracellular space.
It is a highly controlled process carried out by a class of membrane proteins called hyaluronic acid synthetase, consisting of three enzyme subtypes called HAS1, HAS2, HAS3, which act using the nucleotide uridine diphosphate (UDP) capable of alternatingly binding molecules of glucuronic acid and N-acetylglucosamine to the increasing terminal chain, until it reaches a molecular weight of about 4 million daltons.
ROLE OF MOLECULAR WEIGHT AND FUNCTION OF RECEPTORS
It has been shown that the length of HA chains plays an important biological role, because the molecular weight of hyaluronic acid has different effects on cell behavior.
• short chains seem to stimulate proliferation and induce the onset of transductive waterfalls, which may be involved in angiogenesis and inflammatory responses;
• the longer and heavier chains of HA inhibit cell proliferation in vitro.
The formation of smaller fragments of hyaluronic acid can however take place also thanks to a mechanism called degradation. In fact, in the body there are physiologically present enzymes capable of breaking large molecules of hyaluronic acid by hydrolyzing the β1-4 bonds between the residues of N-acetyl-D-glucosamine and D-glucuronic acid. These enzymes are called hyaluronidase, β-D-glucuronidase and β-N-acetyl-hexosaminidase.
Degradation leads to the formation of very low molecular weight hyaluronic acid, which exhibits different properties and a lower viscosity which increases its tissue permeability.
Once formed, the HA produced has a physiological turnover of 10-100 mg / day in adult men and is mainly metabolized by liver endothelial cells and eliminated by the kidneys.
Hyaluronic acid performs its function by covalently binding to a variety of proteins, called ialaderins, influencing their function: these proteins are called binding proteins and include, among others, CD44, RHAMM, TNFIP6, Brevicano, SHAP, LYVE1 receptors. Some of these are found in the extracellular matrix (ECM), some bound to cell membranes.
IMPORTANCE OF CD44 RECEPTORS
Various scientific studies indicate that, among the various receptors, CD44 is the membrane protein that binds the most represented HA: it is a glycoprotein widely expressed in different cell types, and in particular it is abundant in macrophages. Many of the properties recognized to hyaluronic acid seem to be due precisely to the ability to interact with CD44, in fact the interaction with this receptor plays an important role in the development and resolution of inflammation, in the activation and recruitment of T cells, in growth and tumor metastases.
HA is also able to influence behaviors such as cell proliferation, differentiation and migration.
Based, therefore, on the synthesis of all the studies and experiences related to the use of hyaluronic acid and amino acids, Mesorga created Biorej®, a sterile injectable class 3 medical device, based precisely on biostimulation caused by the activation of CD44 receptors; in fact, among the various receptors present on the surface of fibroblasts, the formation of reticular collagen, that is the characteristic collagen of young skin, is induced by CD44, capable of carrying out therefore, if correctly stimulated, a real dermal regeneration.
It is now scientifically proven that the activation of CD44 receptors is possible only in 2 ways:
A) through the use of platelet growth factors;
B)through the use of products based on “fragments” of hyaluronic acid in a range between 20 and 38 monomers.
Dejale is a Biostimulant based on hyaluronic acid with a medium high molecular weight ( 1,2-1,8 x 106 Dalton)hyaluronic acid biorevitalizing treatment.
Biostimulation is a treatment aimed at improving the aesthetic appearance of the skin, of the treated area through the stimulation of the structures responsible for maintaining the trophism, elasticity and tone of the tissues.
The treatment involves the introduction into the skin of medium and high molecular weight macromolecular hyaluronic acid to activate the fibroblasts: the activated fibroblast is stimulated to produce the components of the dermis matrix restoring the natural morphology of the skin, toning the toxic areas and giving freshness expressive.
It is indicated in the physiological process of skin aging, whose effects include:
thickening of the corneum stratum (roughness and reduced luminosity of the skin, dyschromia) and alteration of the dermis (wrinkles).
in the dermal tissue repair process
in cases of scarring as a result of superficial skin trauma (e.g. acne scars and stretch marks)
This treatment can be applied to the face and to any other part of the body that you want to treat. It has the purpose of:
improve skin hydration
improve the elasticity and turgidity of the skin
improves skin compactness by restructuring the extracellular matrix
favors the activity of fibroblasts with formation of new collagen and elastin fibers
scavenger action on free radicals
limits actinic keratosis
Facial Area €600 for 5 therapies (€150 discount)
Facial and Neck Area €720 for 5 treatments. (€180 discount)
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