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Glass Skin Mesotherapy

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Mesotherapy is a medical treatment that involves the intradermal administration of active substances through multiple micro-injections for correcting aesthetic concerns.
The goal of mesotherapy in skin rejuvenation is to increase the biosynthetic capacity of fibroblasts with the reconstruction of an optimal physiological environment, enlargement of cellular activity, and production of new collagen, elastin, and hyaluronic acid, leading to increased firmness, brightness, and moisturization of the skin. Injection into the superficial dermis of suitable products, perfectly biocompatible and totally biodegradable, can provide this. Decreasing of wrinkles is also possible when the procedure is repeated over time. Mesotherapy in skin rejuvenation is also known as biorejuvenation, biorevitalization, or mesolift.

Mesotherapy with mesogun injector can be used anywhere on the face including eye area, body and scalp.

With sun damage and progressive reductions in collagen and hyaluronic acid content, the skin loses its plumpness and resiliency. When used for skin rejuvenation, mesotherapy infuses the superficial dermis with potent vitamins, vasodilators, and antioxidants to rejuvenate and revitalize the skin. Injecting into the skin substances necessary for its proper functions seems to be more efficient than applying topical products.
It is easy to understand that there is no absorption problem because these vitamins are injected directly into the dermis.
• Vitamin A regulates turnover of the epidermis and acts on skin flexibility; it helps healing and partially corrects dermis atrophy. • The vitamin B complex – vitamins B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenate), B6 (pyridoxine), B9 (folic acid), and B12 (cyanocobalamin) – are coenzymes in several metabolic processes that help to scavenge free radicals.
• Vitamin C stimulates collagen synthesis and inhibits melanin (acting together with vitamin E).
• Vitamin E is a strong antioxidant because of its anti-free-radical activity.
• Vitamin K has an effect on the microcirculation.
• Also important are vitamins D, H (biotin), B10 and I (inositol).

Amino acids
The cocktail contains 24 amino acids, which are stable, water-soluble and part of the structure of proteins. They build polypeptides, which form the matrix of the cellular architecture. A specific supplementation may restructure or repair the protein structure of tissue that has been damaged by photoaging, smoking, or other causes

Sodium, potassium, calcium and magnesium act as catalysts of numerous cell functions.

These are non-protein organic components that aid the catalytic function of enzymes. They are ‘activators’ of biochemical reactions and help the turnover of the dermis.
Nucleic acids
DNA and RNA encode the information for polypeptide and protein synthesis from amino acids

Hyaluronic acid
Hyaluronic acid (HA) was discovered in 1934 by Meyer and Palmer in the ocular bovine vitreous. It is a naturally occurring glycosaminoglycan that, by virtue of its viscosity, elasticity, and other rheological properties, acts as an ocular lubricant and as a lubricating and shock absorbing fluid in joints. It is produced by fibroblasts within the cell membrane and then released into the extracellular space. Within the skin, it plays an important role in the hydration of extracellular space; it constitutes a matrix for supporting the normal functions of the cells; it also has functions in space filling, lubrication, wound healing, modulation of inflammatory cells, and scavenging of free radicals.2–7 The HA concentration in the epidermis is 15 μg/g and in the dermis it is 740 μg/g; the molecular mass of HA in the skin is 1 kDa. Native HA is a linear polysaccharide chain similar to HA in the dermis. It is a translucent viscoelastic gel that can be obtained in a highly purified form from rooster combs or through bacterial fermentation. It does not have species specificity and the risk of a hypersensitivity reaction is so low that skin testing is not necessary. Its molecular mass varies between 0.1 and 2.5 kDa. One gram of HA can bind up to 6 liters of water. This means that the higher the percentage of HA in a product (mg of HA beads per ml), the higher its capacity will be to 10 CHAPTER 2: PRODUCTS retain water. The greater the molecular mass of HA, the slower is its degradation in the skin, and so its hydration capacity is higher. It is preferable to choose a high molecular mass than a high concentration. HA utilized for mesotherapy is not crossinked, it is not highly stabilized, it is very fluid, and it resists for a shorter period than HA used for fillers (the time for degradation by hyaluronidase is much shorter). The viscoelastic and moisturizing properties of HA maintain a good hydration status of the dermis, which has two advantages: it provides good flexibility to the extracellular matrix and a stock of water sufficient to hydrate the very superficial layers of the epidermis. During the skin aging process, there is a continuous reduction in the level of HA, which leads to a drastic reduction in the hydration capacity of the skin, as shown by the deterioration of the mechanical properties of the dermis – i.e., loss of elasticity and turgor (Figure 2.2).1,8,9 Every 10 years (with individual variations), the skin loses 6% of its thickness. Reversal of this process was investigated by injecting HA directly with the dermis (through multipunctures) and then observing the restored hydration, elasticity and turgor

With mesotherapy, the skin appears firmer, brighter, and better moisturized. Typically two or three treatments are necessary to see these results – although the brightness may be visible after the first due to vascular stimulus by the microinjections. The number of treatments varies from patient to patient and depends on the treated area and the patient’s expectations. Maintenance of the results is related to the patient’s lifestyle. Performing mesotherapy on young skin is, of course, different from performing it on aging skin. It is important to remember also that mesotherapy is not a filling technique, but permits the rejuvenation of the skin by increasing its hydration and by reconstructing an optimal physiological environment for the fibroblasts. Mesotherapy improves the skin globally; fillers and botulinum toxin improve the skin only locally, in the areas where they are injected.

Growth factors
Human skin is a living organ, which performs dynamic activities such as growth, repair, and maintenance. To maintain these activities, skin requires cytokines and growth factors as key modulators. Generally, the expression levels of cytokines and growth factors, as well as growth hormone levels, decrease with skin aging. When cytokines and growth factors are put into aged skin, this can result in improved skin elasticity and a rejuvenated appearance. Human growth factors and cytokines are now being produced by recombinant engineering similar to the process required for making growth hormone, insulin, oxytocin and erythropoietin. These products are available in various cosmetic forms (cosmeceuticals) as well as in a lyophilized form, which can be used for facial mesotherapy. The following are among the most important products used.

EGF (epidermal growth factor)
EGF is composed of 53 amino acids and can be found in different concentrations in milk, saliva, urine, and plasma, and also in most other body fluids. This protein hastens blood vessel synthesis around damaged parts and drives the secretion of rejuvenating promotional factors. EGF promotes proliferation of fibroblasts, which synthesize collagen and elastin, and epidermal cell growth by driving cell division. EGF induces biosynthesis of hyaluronic acid through interaction with basic fibroblast growth factor (see below). It controls the generation of most cytokines acting on the skin and affects growth and differentiation of the cell by controlling the generation time of each cytokine.

bFGF (basic fibroblast growth factor)
bFGF promotes cell multiplication and division for the extracellular matrix of the dermis, fibroblasts, neurons, endothelial cells, keratinocytes, chondrocytes, myoblasts, osteoblasts, and many other cell types, and strongly protects neurons. It improves the elasticity of the skin and smoothes out wrinkles by increasing the biosynthesis of collagen and elastin. bFGF can increase the biosynthesis of hyaluronic acid when interacting with EGF and insulin-like growth factor I.

IGF-I (insulin-like growth factor I)
IGF-I is a 7.6 kDa single-chain polypeptide hormone structurally similar to proinsulin. It is involved in the formation of bone, muscle, and nerve tissue, and improves the regeneration of damaged cells. It hastens the biosynthesis of hyaluronic acid.

TRX (thioredoxin)
TRX is a strong antioxidant. It affects cell growth by controlling the DNA-binding ability of transcriptional factors. It increases the manifestation of IL-8 and other cytokines.

Use of growth factors
For facial mesotherapy, cocktails of different growth factors are used – for example, a solution of: • EGF • bFGF • IGF-I • TRX • copper peptide • multivitamins and amino acids These solutions must be refrigerated and used within days of opening. They can be mixed with lidocaine or derivatives. Different protocols can be found in the literature, according to the type of product used (e.g., once a week for 4–5 weeks, then once every 2 weeks for 2–3 months and once every 1–2 months).
Growth factors can be added to other products used in facial mesotherapy to enhance the effect. The results vary from discreet to moderate, and there is no consensus in the literature regarding products, protocols, or effectiveness.

✔Little to no downtime
✔Effective for all skin types, light to dark
✔Comfortable experience and ideal any time of the year
✔Short procedure time
✔Real results from a safe, natural and minimally invasive procedure
✔Clinically proven safe and effective



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